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Colorectal carcinoma (CRC) is a leading cause of cancer-related deaths globally, ranking second in mortality rates. Cancer progression is influenced not only by genetic mutations in tumour cells but also by th...
Bone metastases rank third in prevalence among metastatic afflictions, following lung and liver. Historically linked to breast, prostate, and lung cancers, evolving cancer therapies now reveal skeletal metasta...
Head and neck squamous cell carcinoma (HNSCC) is a significant global health concern, constituting about 4.5% of all cancer diagnoses and fatalities. Tumor budding, characterized by single cells or small clust...
The occurrence of ectopic prostatic tissue in the female genital tract is an extremely rare condition, usually discovered incidentally. This anomaly has been reported in various parts of the genital tract, inc...
Merkel cell carcinoma is a very rare and aggressive primary cutaneous neuroendocrine carcinoma with rapid growth and a risk of early metastasis and regional recurrence despite treatment.
Bullous pemphigoid (BP) is the most common type of subepidermal bullous disease. The detection of linear deposition of immunoglobulin G (IgG) and/or C3 at the dermo-epidermal junction using direct immunofluore...
Melanoma is an aggressive form of skin cancer. Its histopathological diagnosis may be challenging and subject to significant inter- and intraobserver variability. It is also a disproportionate source of pathol...
Limb Girdle Muscular Dystrophy is defined as a group of progressive autosomal recessive (85%, 28 genes) and autosomal dominant (15%, 5 genes) muscular dystrophies described in at least two unrelated families, ...
Wnt/β-catenin pathway has an important role in hepatocarcinogenesis. It has been involved in progression, growth, epithelial mesenchymal transition and metastasis of hepatocellular carcinoma (HCC). This pathwa...
Local recurrence and distant metastasis after curative surgery and chemotherapy for colorectal cancer (CRC) is a serious complication and is considered a failure of the therapeutic strategy. The aim of this st...
The International Academy of Cytology (I.A.C.) Yokohama System to report breast cytopathology can effectively categorize breast diseases into different cytological groups. Fine needle aspiration (FNAC) from th...
Preferentially expressed antigen in melanoma (PRAME) is a promising immunohistochemical marker for distinguishing benign from malignant melanocytic lesions in lymph node deposits.
Triple coronary artery thrombosis is a rare cause of acute myocardial infarction, and is associated with high mortality. Only a few cases of simultaneous multiple-vessel coronary thrombosis have been reported ...
The prevalence of breast cancer is increasing globally and its early detection is the need of hour for giving the patient a long disease-free meaningful life. The latest management regimes depend upon the biol...
Neuromuscular disorders are characterized by disturbances in any part of the neurologic pathways, including: the Central Nervous System, the motor neuron of the anterior horn of the spinal cord; the peripheral...
Every branch of surgery relies in some way on histology to obtain a conclusive diagnosis. Since precise and comprehensive information on the request form is crucial to the correct analysis and interpretation o...
Sarcomas are tumors of mesenchymal origin that remain with poor prognosis. This review highlights some emerging predictive biomarkers that could drive personalized therapy, focusing on KIT, TP53, MDM2, CDK4 mu...
Most pediatric kidney tumors clinically present as an abdominal mass, typically detected by the child’s caregivers and later confirmed through imaging tests. Malignant renal cancers account for approximately 5...
Endometrial carcinoma (EC) is the most common gynecologic malignancy in high-income countries, with its incidence and mortality rising globally, particularly in countries undergoing rapid socioeconomic transit...
Predictive biomarkers of response to therapy are fundamental for the personalized therapeutic management of patients with colorectal carcinoma (CRC). The main predictive biomarkers related to CRC are the misma...
Gastric cancer is the fifth most common cause of cancer-related deaths globally, with a decreasing but still high number of cases. Although there have been improvements in treatment choices, the expected survi...
Hirschsprung’s disease (HD) is a neurogenic intestinal disorder attributed to incomplete neural crest cell migration during fetal intestinal development, leading to an aganglionic segment of the colon and func...
Low grade endometrial stromal sarcoma (LGESS) typically presents as a solid intracavitary or intramural uterine mass. On imaging, LGESS is usually seen as an endometrial or myometrial solid mass. Cystic change...
Cholangiocarcinoma, a malignant neoplasm of the biliary system, poses a significant challenge in clinical practice due to its increasing incidence and diagnostic and therapeutic complexity. This review address...
Urologic pathology is rapidly evolving to adopt growing knowledge of molecular pathways involved in genitourinary neoplasm. Many prognostic and predictive biomarkers are under active research and some of them ...
Thyroid cancer is one of the most common types of cancer worldwide. It is a spectrum of different diseases, ranging from very indolent to lethal tumors. Differentiated Thyroid Carcinoma (DTC), the most common ...
Since the FDA approved immune-enhancing therapies for patients with high microsatellite instability (MSI-H) and/or mismatch repair deficiency (dMMR), recognizing these biomarkers in solid tumors has gained cli...
Telethoninopathy or TCAP-gene related Limb Girdle Muscular Dystrophy is a rare genetic disease that was first described in Brazil. There are around 100 families reported worldwide. Due to its rarity, detailed inf...
The aim of the current study was to molecularly determine Bcl-2 and BAX gene mutations in HPV-associated squamous cell carcinoma of the cervix.
Situs inversus is a rare congenital anomaly. In this condition, the abdominal and chest organs are positioned in reverse, a mirror image of the normal anatomical position. It is divided into two categories. 1....
Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive lymphoma defined by the proliferation of atypical lymphoma cells in the lumen of all sized blood vessels, particularly capillaries....
The Brazilian Society of Pathology Guidelines Project aims to provide recommendations for clinicians and pathologists based on the best available scientific evidence. It reviews the currently available and emergi...
We report a case of an adult ileocolic intussusception secondary to an inflammatory fibroid polyp (IFP), a rare and unexpected association between a surgical condition, and an underlying histopathological proc...
Fine-needle aspiration cytology (FNAC) of the breast is a well-established technique that aids in the preoperative identification and differentiation between nonneoplastic and neoplastic breast lesions. Breast...
The COVID-19 pandemic has led to the need for extraordinary restrictions and adjustments in health services, which may have compromised cancer screening and oncological treatments. The aim of our retrospective...
The impact of COVID-19 pandemic in pregnant patients is an important emerging topic. Evidence of transplacental transmission and typical histopathological alterations in the placenta are controversial in the l...
Lung is susceptible and vulnerable to many infectious and non-infectious agents. From this, a large number of specific and nonspecific diseases conditions can be diagnosed. A cross-sectional study design was c...
Uterine smooth muscle tumor of uncertain malignant potential (STUMP) is a group of uterine smooth muscle tumors which cannot be classified as a subtype of leiomyoma or leiomyosarcoma. Diagnosis, prognosis, and...
Colorectal cancer (CRC) was the third most lethal cancer in 2022 worldwide. Tumor budding (TB) and poorly differentiated clusters (PDC) are prognostic factors. However, the lack of standardization in the asses...
Neoplasms originating from the urachus are exceptionally uncommon, comprising only 0.17% of all bladder neoplasms. Among these, the mucinous cystic tumor of low malignant potential (MCTLMP) is particularly rar...
the aim of the current study was to molecularly classify high-grade, muscle-invasive, urothelial carcinoma of basal, luminal, and p53-like subtypes and to assess their relationship with CTLA-4 and PD-L1 expres...
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is used for cytopathological diagnosis of fine needle aspiration (FNA) of thyroid nodules (TN). Diagnosis of Bethesda Category III (CIII) has estim...
Apocrine metaplastic change is a frequent change in breast pathology. Invasive carcinoma with apocrine differentiation of the breast has unconventional histology, immunohistochemical (IHC), and molecular profi...
Sclerosing Epithelioid Fibrosarcoma is a rare form of soft tissue sarcoma, with increased propensity for local recurrence and metastases mainly pulmonary and pleural in about 50% of cases. It carries morpholog...
The Brazilian Society of Pathology Guidelines project aims to provide recommendations for clinicians and pathologists based on the best available scientific evidence adapted from the International Guidelines, ...
Primary intra-axial Ewing sarcoma (EWS) is extremely rare and a highly aggressive small blue round cell tumor in the central nervous system (CNS). We reported a case of primary intra-axial CNS-EWS in a 30-year...
The development of personalized medicine using high-throughput methods, such as metabolomics profiling, in discovering and validating biomarkers, may play a key role in the development of new and non-invasive ...
Digital pathology (DP) adoption in Latin America has expanded slower than in developed regions, probably due to many barriers not seen in the latter areas. This article aims to present the current scenario in ...
The original article was published in Surgical and Experimental Pathology 2023 6:6
Primary anorectal melanoma is a rare and aggressive disease accounting for approximately 1–3% of all colorectal and anal cancers.
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