Fig. 1
From: Advancements and challenges in gastric cancer: epidemiology, biomarkers, and therapeutic strategies
AÂ Different immunohistochemistry patterns of Mismatch repair protein. IHC for MSH2 shows a strong immune reaction with intact nuclear staining in neoplastic cells indicating a proficient system (pMMR); BÂ IHC for MLH1 reveals a loss of tumor cell nuclear staining with intact positive internal control, in a deficient system (dMMR)