Fig. 1
From: Predictive biomarkers in thyroid cancer in the current molecular-morphology paradigm

Schematic representation of MAPK-ERK and PI3K-AKT pathways. Dimerization and phosphorylation of the various Kinase Receptors’ intracytoplasmic Kinase domain triggers phosphorylation and activation of following components, which allows transmission of extracellular signals to the nucleus