Fig. 4

Fumarate hydratase – deficient renal cell carcinoma. Tubulocystic growth intermixed with a solid component (a HE, 100x). Higher magnification shows prominent nucleoli (b HE, 400x). Fumarate hydrase immunostain show loss of cytoplasmatic staining in tumor cells while expression is retaining in adjacent stromal cells (c and d 40x and 400x)