Fig. 2

Example of a ≤ 1.0 cm lesion diagnosed via FNAC and confirmed via histopathological examination. Mammographic examination (a) and ultrasound examination (b) demonstrate a suspected irregular lesion for malignancy. The FNAC specimen was stained with MGG (#) and HE (&) and also prepared for cellblock (*) (c). On MGG (d) and HE (e) staining, the specimen show characteristics of a well-differentiated carcinoma, consisting of loose cells or forming small clusters with low cohesiveness. Histological sections of the cellblock show atypical epithelial cells similar to smears (f). Macroscopic examination of a quadrantectomy shows a 0.5 cm lesion surrounded by adipose tissue (→) (g). Histological sections stained using HE confirm the diagnosis of classic lobular carcinoma (h, i and j). Abbreviations: FNAC: fine-needle aspiration cytology; MGG: May-Gründwald-Giemsa; HE: hematoxylin-eosin